you can count the number of factors of $p$ that are in $\binom{n}{k}$ for prime $p$. Let $s_p(n)$ be the sum of the digits of $n$ in base $p$. Then, the number of factors of $p$ in $\binom{n}{k}$ is $(s_p(k)+s_p(n-k)-s_p(n))/(p-1)$.
Answer
It's a corollary of Legendre's 1808 theorem that power of the prime $p$ that divides $n!$ is
$$ [n/p] + [n/p^2] + [n/p^3] +\: \cdots\ =\ \frac{n-s_p(n)}{p-1}$$
For this and much more see Andrew Granville's very interesting survey The Arithmetic Properties of Binomial Coefficients.
A full answer is here.
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